Linked Life Data

1938284

Source:http://linkedlifedata.com/resource/pubmed/id/1938284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1991-12-23
pubmed:abstractText
Binocular beat VEPs were recorded from anesthetized macaque monkeys with diverse visual rearing histories, including surgically induced esotropia, optical prism dissociation, optical anisometropia, monocular form deprivation (MD), and normal rearing. Dichoptic visual stimulation was produced by temporally modulating the luminances of uniform fields presented to each eye. Five pairs of temporal frequencies were used, all of which had interocular differences of 2 Hz. While normally reared animals exhibited robust binocular beat responses strongly tuned to temporal frequency, the responses from monkeys with abnormal rearing experiences showed losses in beat signal-to-noise ratios that correlated with the age of onset or duration of the abnormal visual experience. Surgical esotropia induced early in life (2 months of age) produced a virtually complete loss of the binocular beat response; the cortical losses were less severe as the age of surgery rose to 10 months. Monkeys reared with either anisometropia or optical dissociation also manifested substantial reductions in evoked beat nonlinearity. MD monkeys sutured relatively late in development (8 and 25 months) showed mild reductions. The correspondence of these results to earlier psychophysical data obtained from these animals, and the similarity of these results to previous findings with binocularly normal and abnormal humans, supports the use of the binocular beat as an objective, noninvasive index of binocular neural integrity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3096-103
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Binocular beat VEPs: losses of cortical binocularity in monkeys reared with abnormal visual experience.
pubmed:affiliation
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas.
pubmed:publicationType
Journal Article, Comparative Study