Source:http://linkedlifedata.com/resource/pubmed/id/19381778
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-3-16
|
| pubmed:abstractText |
The in vitro metabolic stability of histidine-dipeptides (HD), carnosine (CAR) and anserine (ANS), in human serum, and their absorption kinetics after ingesting pure carnosine or HD rich foods in humans have been investigated. Healthy women (n = 4) went through four phases of taking one dose of either 450 mg of pure carnosine, 150 g beef (B), 150 g chicken (C), or chicken broth (CB) from 150 g chicken with a >2-week washout period between each phase. Blood samples were collected at 0, 30, 60, 100, 180, 240, and 300 min, and urine samples before and after (up to 7 h) ingesting pure carnosine or food. Both plasma and urine samples were analyzed for HD concentrations using a sensitive and selective LC-ESI-MS/MS method. CAR was undetectable in plasma after ingesting pure carnosine, B, C or CB. By contrast, plasma ANS concentration was significantly increased (P < 0.05) after ingesting C or CB, respectively. Urinary concentrations of both CAR and ANS were 13- to 14-fold increased after ingesting B, and 14.8- and 243-fold after CB ingestion, respectively. Thus, dietary HD, which are rapidly hydrolyzed by carnosinase in plasma, and excreted in urine, may act as reactive carbonyl species sequestering agents.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1438-2199
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
847-58
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| pubmed:meshHeading |
pubmed-meshheading:19381778-Adult,
pubmed-meshheading:19381778-Animals,
pubmed-meshheading:19381778-Anserine,
pubmed-meshheading:19381778-Carnosine,
pubmed-meshheading:19381778-Cattle,
pubmed-meshheading:19381778-Chickens,
pubmed-meshheading:19381778-Chromatography, High Pressure Liquid,
pubmed-meshheading:19381778-Female,
pubmed-meshheading:19381778-Humans,
pubmed-meshheading:19381778-Kinetics,
pubmed-meshheading:19381778-Lung,
pubmed-meshheading:19381778-Male,
pubmed-meshheading:19381778-Meat,
pubmed-meshheading:19381778-Middle Aged,
pubmed-meshheading:19381778-Poultry Products,
pubmed-meshheading:19381778-Rats,
pubmed-meshheading:19381778-Rats, Wistar,
pubmed-meshheading:19381778-Tandem Mass Spectrometry,
pubmed-meshheading:19381778-beta-Alanine
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans.
|
| pubmed:affiliation |
Jean Mayer USDA, Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111, USA. kyungjin.yeum@tufts.edu
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Validation Studies
|