Linked Life Data

19381633

Source:http://linkedlifedata.com/resource/pubmed/id/19381633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-2-3
pubmed:abstractText
We show that the cooperative model for the kinetics of a tetrameric potassium ion channel derived in Nekouzadeh et al. (Biophys J 95(7):3510-3520, 2008) is an invariant manifold reduction of the full master equation for the channel kinetics. We further establish the validity of this reduction for ion channel models consisting of multiple independent subunits with cooperative transitions from a single permissive state to a conducting state. Finally, we conclude that solutions of the reduced model are globally asymptotically stable solutions of the full master equation system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1432-1416
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Exact reductions of Markovian dynamics for ion channels with a single permissive state.
pubmed:affiliation
Department of Mathematics, University of Utah, Salt Lake City, UT, 84112, USA. keener@math.utah.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.