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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1991-12-24
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pubmed:abstractText |
The expression of T-cell-associated serine proteinase 1 (MTSP-1) in vivo during Leishmania major infection was analyzed in genetically resistant C57BL/6 mice and in genetically susceptible BALB/c mice. Using a monoclonal antibody as well as an RNA probe specific for MTSP-1 to stain tissue sections, we found T cells expressing MTSP-1 in skin lesions and spleens of mice of both strains. In skin lesions, MTSP-1-positive T cells could be detected as early as 3 days after infection. Most importantly, the frequency of T cells expressing MTSP-1 was significantly higher in susceptible BALB/c mice than in resistant C57BL/6 mice. These findings suggest that MTSP-1 is associated with disease-promoting T cells and that it may be an effector molecule involved in the pathogenesis of cutaneous leishmaniasis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-1710925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-1976523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2137093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2201340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2422755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2523952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2584937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2668013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-2784104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3060134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3094960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3127233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3259538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3259928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3264023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3280725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3488814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3488903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3489187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3545816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3546101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-3546576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-6120976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-6202760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1937831-6443342
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4701-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1937831-Animals,
pubmed-meshheading:1937831-CD4-CD8 Ratio,
pubmed-meshheading:1937831-Disease Susceptibility,
pubmed-meshheading:1937831-Female,
pubmed-meshheading:1937831-Leishmania tropica,
pubmed-meshheading:1937831-Leishmaniasis, Cutaneous,
pubmed-meshheading:1937831-Mice,
pubmed-meshheading:1937831-Mice, Inbred BALB C,
pubmed-meshheading:1937831-Mice, Inbred C57BL,
pubmed-meshheading:1937831-Serine Endopeptidases,
pubmed-meshheading:1937831-T-Lymphocytes
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pubmed:year |
1991
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pubmed:articleTitle |
Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease.
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pubmed:affiliation |
Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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