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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-6-15
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pubmed:abstractText |
The inflammatory responses of monocytes/macrophages and the stimulation of lipid uptake into these cells by oxidized low density lipoprotein (oxLDL) are critical to the initiation and development of atherosclerosis. Increasing evidence has demonstrated that many microRNAs play important roles in the cell proliferation, apoptosis, and differentiation that accompany inflammatory responses. However, whether microRNAs are associated with monocyte/macrophage inflammatory responses or oxLDL stimulation is not yet known. The aim of the present study is to investigate microRNAs in monocytes/macrophages and their potential role in oxLDL-stimulation of lipid uptake and other atherosclerotic responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/MIRN125 microRNA, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/oxysterol receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19377067-Apoptosis,
pubmed-meshheading:19377067-Cell Differentiation,
pubmed-meshheading:19377067-Cell Proliferation,
pubmed-meshheading:19377067-Cells, Cultured,
pubmed-meshheading:19377067-Down-Regulation,
pubmed-meshheading:19377067-Humans,
pubmed-meshheading:19377067-Inflammation,
pubmed-meshheading:19377067-Interleukin-2,
pubmed-meshheading:19377067-Interleukin-6,
pubmed-meshheading:19377067-Lipid Metabolism,
pubmed-meshheading:19377067-Lipoproteins, LDL,
pubmed-meshheading:19377067-Macrophages,
pubmed-meshheading:19377067-MicroRNAs,
pubmed-meshheading:19377067-Monocytes,
pubmed-meshheading:19377067-Receptors, Steroid,
pubmed-meshheading:19377067-Transforming Growth Factor beta,
pubmed-meshheading:19377067-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19377067-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages.
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pubmed:affiliation |
Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, Peoples Republic of China. ting010151452@yahoo.com.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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