Source:http://linkedlifedata.com/resource/pubmed/id/19372257
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2009-9-4
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| pubmed:abstractText |
It has been found that c-Myc protein plays a critical role in controlling self-renewal versus differentiation in hematopoietic stem cells. We report that c-Myc also controls the fate of megakaryocyte-erythrocyte progenitors through regulating the differentiation of erythroid and megakaryocytic progenitors. In addition to the significant reduction of granulocytes/macrophages and B and T lymphocytes because of the reduction of their corresponding progenitors, we found significantly increased numbers of megakaryocytic progenitors and mature megakaryocytes in bone marrow and spleens of c-Myc-knockout (c-Myc(-/-)) mice. Differentiation of erythrocytes was blocked at the erythroid progenitor stage. This increased megakaryocytopoiesis is a cell-intrinsic defect of c-Myc-mutant hematopoietic stem cells, as shown by transplantation studies. Furthermore, we found that c-Myc is required for polyploidy formation but not for cytoplasmic maturation of megakaryocytes. Megakaryocytes from c-Myc(-/-) mice are significantly smaller in size and lower in ploidy than those of control mice; however, because of the dramatic increase in megakaryocyte number, although fewer platelets are produced by each megakaryocyte, a greater than 3-fold increase in platelet number was consistently observed in c-Myc(-/-) mice. Thus, c-Myc(-/-) mice develop a syndrome of severe thrombocytosis-anemia-leukopenia because of significant increases in megakaryocytopoiesis and concomitant blockage of erythrocyte differentiation and reductions in myelolymphopoiesis.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1528-0020
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| pubmed:author |
pubmed-author:AlkanSerhanS,
pubmed-author:BreslinPeterP,
pubmed-author:CrumJ DJD,
pubmed-author:DiazManuelM,
pubmed-author:GuoYinshiY,
pubmed-author:KiniAmeet RAR,
pubmed-author:MorrisStephan WSW,
pubmed-author:PanerGladell PGP,
pubmed-author:StiffPatrick JPJ,
pubmed-author:TangMinghuiM,
pubmed-author:XXX,
pubmed-author:ZhangJiwangJ,
pubmed-author:ZhangShubinS
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
3
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2097-106
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| pubmed:dateRevised |
2010-9-6
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| pubmed:meshHeading |
pubmed-meshheading:19372257-Anemia,
pubmed-meshheading:19372257-Animals,
pubmed-meshheading:19372257-B-Lymphocytes,
pubmed-meshheading:19372257-Blood Platelets,
pubmed-meshheading:19372257-Bone Marrow,
pubmed-meshheading:19372257-Cell Differentiation,
pubmed-meshheading:19372257-Cell Size,
pubmed-meshheading:19372257-Erythrocytes,
pubmed-meshheading:19372257-Erythroid Precursor Cells,
pubmed-meshheading:19372257-Granulocytes,
pubmed-meshheading:19372257-Leukopenia,
pubmed-meshheading:19372257-Macrophages,
pubmed-meshheading:19372257-Megakaryocyte Progenitor Cells,
pubmed-meshheading:19372257-Megakaryocytes,
pubmed-meshheading:19372257-Mice,
pubmed-meshheading:19372257-Mice, Knockout,
pubmed-meshheading:19372257-Ploidies,
pubmed-meshheading:19372257-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:19372257-T-Lymphocytes,
pubmed-meshheading:19372257-Thrombocytosis,
pubmed-meshheading:19372257-Thrombopoiesis
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.
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| pubmed:affiliation |
Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|