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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1991-12-6
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pubmed:abstractText |
Metabolic glucose control was followed in 36 patients at 12-month intervals for up to 5 years after a successful combined kidney and segmental duct-occluded pancreas transplantation. All recipients had normal blood glucose levels at each examination. HbA1 values, intravenous glucose tolerance test, C-peptide levels and C-peptide responses to glucagon stimulation were also, on average, within the normal range. Several individual patients had, however, abnormal values for these parameters. At most 46% had abnormal values for HbA1 and intravenous glucose tolerance test, up to 13% showed low C-peptide values and up to 46% of the stimulated C-peptide responses were inadequate at the different intervals. These parameters did not deteriorate with time. This was true both for the whole group of patients as well as for the 6 patients with a 5-year observation time evaluated separately. Despite these abnormalities in glucose metabolism, all patients remained normoglycaemic without need for exogenous insulin up to 5 years after transplantation. The long-term ability of duct-occluded segmental pancreatic grafts to preserve euglycaemia therefore seems to remain intact at least for 5 years.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-186X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
S68-70
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1936699-Adult,
pubmed-meshheading:1936699-Blood Glucose,
pubmed-meshheading:1936699-C-Peptide,
pubmed-meshheading:1936699-Diabetes Mellitus, Type 1,
pubmed-meshheading:1936699-Diabetic Nephropathies,
pubmed-meshheading:1936699-Follow-Up Studies,
pubmed-meshheading:1936699-Glucagon,
pubmed-meshheading:1936699-Glucose Tolerance Test,
pubmed-meshheading:1936699-Hemoglobin A, Glycosylated,
pubmed-meshheading:1936699-Humans,
pubmed-meshheading:1936699-Immunosuppressive Agents,
pubmed-meshheading:1936699-Kidney Transplantation,
pubmed-meshheading:1936699-Pancreas Transplantation,
pubmed-meshheading:1936699-Reference Values,
pubmed-meshheading:1936699-Uremia
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pubmed:year |
1991
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pubmed:articleTitle |
Long-term metabolic control in recipients of combined pancreas and kidney transplants.
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pubmed:affiliation |
Department of Internal Medicine, National Hospital, University of Oslo, Norway.
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pubmed:publicationType |
Journal Article
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