Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-13
pubmed:abstractText
Lung cancer is the leading cause of cancer-related mortality in the United States. Patients treated with adjuvant chemotherapy have a 5-year survival rate of 25% to 70% depending on stage, whereas those with advanced disease have a median survival of approximately 8 months when treated with standard platinum-based therapy. Improvements in our understanding of cancer biology have led to the development of novel agents that more precisely affect the target of interest, allowing for a more rational approach to clinical trial design. Angiogenesis, the growth of new vessels from preexisting vessels, is a fundamental step in tumor growth and progression. Inhibition of tumor-related angiogenesis has become an attractive target for anticancer therapy. Bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), is the most studied antiangiogenic agent in patients with non-small-cell lung cancer (NSCLC). There was an improvement in overall survival when bevacizumab was combined with paclitaxel and carboplatin in patients with advanced NSCLC that was not seen when bevacizumab was combined with cisplatin and gemcitabine. Studies with bevacizumab in the adjuvant and advanced setting are ongoing in patients with NSCLC. Small-molecule inhibitors targeting the VEGF receptor and the tyrosine kinase receptor have also shown promise when combined with standard chemotherapy, but their role in the treatment of patients with NSCLC remains to be determined. This article reviews clinical trials that have incorporated antiangiogenic agents in the treatment of patients with NSCLC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized, http://linkedlifedata.com/resource/pubmed/chemical/Benzenesulfonates, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/N-(4-bromo-2-fluorophenyl)-6-methoxy..., http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial..., http://linkedlifedata.com/resource/pubmed/chemical/Thalidomide, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/bevacizumab, http://linkedlifedata.com/resource/pubmed/chemical/sorafenib, http://linkedlifedata.com/resource/pubmed/chemical/sunitinib
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1525-7304
pubmed:author
pubmed:issnType
Print
pubmed:volume
10 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S7-16
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19362948-Angiogenesis Inhibitors, pubmed-meshheading:19362948-Antibodies, Monoclonal, pubmed-meshheading:19362948-Antibodies, Monoclonal, Humanized, pubmed-meshheading:19362948-Benzenesulfonates, pubmed-meshheading:19362948-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:19362948-Clinical Trials as Topic, pubmed-meshheading:19362948-Humans, pubmed-meshheading:19362948-Indoles, pubmed-meshheading:19362948-Lung Neoplasms, pubmed-meshheading:19362948-Piperidines, pubmed-meshheading:19362948-Protein Kinase Inhibitors, pubmed-meshheading:19362948-Pyridines, pubmed-meshheading:19362948-Pyrroles, pubmed-meshheading:19362948-Quinazolines, pubmed-meshheading:19362948-Receptors, Vascular Endothelial Growth Factor, pubmed-meshheading:19362948-Thalidomide, pubmed-meshheading:19362948-Vascular Endothelial Growth Factor A
pubmed:year
2009
pubmed:articleTitle
Emerging data with antiangiogenic therapies in early and advanced non-small-cell lung cancer.
pubmed:affiliation
Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
pubmed:publicationType
Journal Article, Review