rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1991-11-25
|
pubmed:abstractText |
The base exchange enzymes catalyze the incorporation of L-serine, ethanolamine and choline into their corresponding phospholipids. The L-serine base enzyme activity was increased 120% by 0.1 mM sphingosine. There was a modest increase of the ethanolamine base exchange enzyme activity but the choline base exchange enzyme activity was unaffected. Na-arachadonate, Na-oleate and Na-linolenate at 0.2 mM concentration increased the activity of the L-serine and ethanolamine base exchange enzymes but inhibited the choline base exchange enzyme activity. A model is proposed suggesting that modulations of the L-serine base exchange enzyme may participate in the regulation of the calcium phospholipid-dependent protein kinase C.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
7
|
pubmed:volume |
291
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
63-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1936252-Animals,
pubmed-meshheading:1936252-Brain,
pubmed-meshheading:1936252-Cell Membrane,
pubmed-meshheading:1936252-Choline,
pubmed-meshheading:1936252-Diglycerides,
pubmed-meshheading:1936252-Ethanolamine,
pubmed-meshheading:1936252-Ethanolamines,
pubmed-meshheading:1936252-Fatty Acids, Unsaturated,
pubmed-meshheading:1936252-Models, Biological,
pubmed-meshheading:1936252-Nucleotides,
pubmed-meshheading:1936252-Phospholipids,
pubmed-meshheading:1936252-Rats,
pubmed-meshheading:1936252-Serine,
pubmed-meshheading:1936252-Sphingosine
|
pubmed:year |
1991
|
pubmed:articleTitle |
Sphingosine and unsaturated fatty acids modulate the base exchange enzyme activities of rat brain membranes.
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|