Linked Life Data

19361979

Source:http://linkedlifedata.com/resource/pubmed/id/19361979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-5-15
pubmed:abstractText
Recent technological developments have renewed the interest in large-scale neural circuit reconstruction. To resolve the structure of entire circuits, thousands of neurons must be reconstructed and their synapses identified. Reconstruction techniques at the light microscopic level are capable of following sparsely labeled neurites over long distances, but fail with densely labeled neuropil. Electron microscopy provides the resolution required to resolve densely stained neuropil, but is challenged when data for volumes large enough to contain complete circuits need to be collected. Both photon-based and electron-based imaging methods will ultimately need highly automated data analysis, because the manual tracing of most networks of interest would require hundreds to tens of thousands of years in human labor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-6882
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
633-41
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
3D structural imaging of the brain with photons and electrons.
pubmed:affiliation
Max-Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg, Germany. Moritz.Helmstaedter@mpimf-heidelberg.mpg.de
pubmed:publicationType
Journal Article, Review