Linked Life Data

19356271

Source:http://linkedlifedata.com/resource/pubmed/id/19356271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-9-14
pubmed:abstractText
Dietary Si (orthosilicic acid; OSA) appears important in connective tissue health, and although the sources and intakes of Si are well established, its absorption is not. Si absorption was measured from eight high-Si-containing sources: alcohol-free beer; OSA solution (positive control); bananas; green beans; supplemental choline-stabilised OSA (ChOSA); supplemental monomethyl silanetriol (MMST); supplemental colloidal silica (CS); magnesium trisilicate British Pharmacopoeia antacid (MTBP). Two of the supplements and the antacid were pre-selected following an in vitro dissolution assay. Fasting, healthy subjects (CS, n 3; others, n > or = 5) each ingested two of the sources separated by a 1-week wash-out period. Blood and urine were collected and measured for total Si concentrations by inductively coupled plasma optical emission spectrometry. Absorption, based on urinary Si excretion, was highest for MMST and alcohol-free beer (64% of dose), followed by green beans (44%), OSA (43%), ChOSA (17%), bananas and MTBP (4%) and CS (1%). Peak serum concentrations occurred by 0.5 h for MMST and green beans, 1.5 h for OSA and alcohol-free beer, 2 h for ChOSA and CS, and 4 h for MTBP. Area under the serum curves correlated positively with urinary Si output (r 0.82; P < 0.0001). Absorption of Si from supplements and antacids was consistent with their known chemical speciation and kinetics of dissolution under simulated gastrointestinal conditions. Monomeric silicates were readily absorbed, while particulate silicates were decreasingly well absorbed with increasing polymerisation. The present results highlight the need to allow for relative absorption of Si from different foods or supplements in subsequent epidemiological and intervention studies.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-10612067, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-10731501, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-11976163, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-14969400, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-15005826, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-16205932, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-16277785, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-17435952, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-18547426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-2015936, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-6278583, http://linkedlifedata.com/resource/pubmed/commentcorrection/19356271-6636024
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1475-2662
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
825-34
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The comparative absorption of silicon from different foods and food supplements.
pubmed:affiliation
Gastrointestinal Laboratory, The Rayne Institute (King's College London), St Thomas' Hospital, London SE1 7EH, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't