Linked Life Data

19346607

Source:http://linkedlifedata.com/resource/pubmed/id/19346607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 4
pubmed:dateCreated
2009-4-6
pubmed:abstractText
The crystal structure of the hydrated proton-transfer compound of the drug quinacrine [rac-N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine] with 4,5-dichlorophthalic acid, C(23)H(32)ClN(3)O(2+).2C(8)H(3)Cl(2)O(4)(-).4H(2)O, has been determined at 200 K. The four labile water molecules of solvation in the structure form discrete ...O-H...O-H... hydrogen-bonded chains parallel to the quinacrine side chain, the two N-H groups of which act as hydrogen-bond donors for two of the water acceptor molecules. The other water molecules, as well as the acridinium H atom, also form hydrogen bonds with the two anion species and extend the structure into two-dimensional sheets. Between these sheets there are also weak cation-anion and anion-anion pi-pi aromatic ring interactions. This structure represents the third example of a simple quinacrine derivative for which structural data are available but differs from the other two in that it is unstable in the X-ray beam due to efflorescence, probably associated with the destruction of the unusual four-membered water chain structures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1600-5759
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
o131-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Unusual hydrate stabilization in the two-dimensional layered structure of quinacrinium bis(2-carboxy-4,5-dichlorobenzoate) tetrahydrate, a proton-transfer compound of the drug quinacrine.
pubmed:affiliation
School of Physical and Chemical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane 4001, Australia. g.smith@qut.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't