Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-8-27
pubmed:abstractText
Pregabalin (PRE) acts as a presynaptic inhibitor of the release of excessive levels of excitatory neurotransmitters by selectively binding to the alpha(2)-delta subunit of voltage-gated calcium channels. In this randomised, double-blind comparison trial with naltrexone (NAL), we aimed to investigate the efficacy of PRE on alcohol drinking indices. Craving reduction and improvement of psychiatric symptoms were the secondary endpoints. Seventy-one alcohol-dependent subjects were detoxified and subsequently randomised into two groups, receiving 50 mg of NAL or 150-450 mg of PRE. Craving (VAS; OCDS), withdrawal (CIWA-Ar) and psychiatric symptoms (SCL-90-R) rating scales were applied. Alcohol drinking indices and craving scores were not significantly different between groups. Compared with NAL, PRE resulted in greater improvement of specific symptoms in the areas of anxiety, hostility and psychoticism, and survival function (duration of abstinence from alcohol). PRE also resulted in better outcome in patients reporting a comorbid psychiatric disorder. Results from this study globally place PRE within the same range of efficacy as that of NAL. The mechanism involved in the efficacy of PRE in relapse prevention could be less related to alcohol craving and more associated with the treatment of the comorbid psychiatric symptomatology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1461-7285
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1367-74
pubmed:meshHeading
pubmed-meshheading:19346279-Adult, pubmed-meshheading:19346279-Alcohol Withdrawal Delirium, pubmed-meshheading:19346279-Alcohol-Related Disorders, pubmed-meshheading:19346279-Anticonvulsants, pubmed-meshheading:19346279-Anxiety, pubmed-meshheading:19346279-Calcium Channel Blockers, pubmed-meshheading:19346279-Double-Blind Method, pubmed-meshheading:19346279-Female, pubmed-meshheading:19346279-Hostility, pubmed-meshheading:19346279-Humans, pubmed-meshheading:19346279-Male, pubmed-meshheading:19346279-Middle Aged, pubmed-meshheading:19346279-Naltrexone, pubmed-meshheading:19346279-Narcotic Antagonists, pubmed-meshheading:19346279-Obsessive-Compulsive Disorder, pubmed-meshheading:19346279-Severity of Illness Index, pubmed-meshheading:19346279-Substance Withdrawal Syndrome, pubmed-meshheading:19346279-gamma-Aminobutyric Acid
pubmed:year
2010
pubmed:articleTitle
Pregabalin versus naltrexone in alcohol dependence: a randomised, double-blind, comparison trial.
pubmed:affiliation
Department of Psychiatry, Catholic University Medical School, Rome, Italy. giovanni.martinotti@libero.it
pubmed:publicationType
Journal Article, Comparative Study, Randomized Controlled Trial