| pubmed-article:1934296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0009452 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0025920 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0007271 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0061928 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0023775 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C1516463 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1934296 | lifeskim:mentions | umls-concept:C0205144 | lld:lifeskim |
| pubmed-article:1934296 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1934296 | pubmed:dateCreated | 1991-12-19 | lld:pubmed |
| pubmed-article:1934296 | pubmed:abstractText | We have previously demonstrated that diverse carotenoids inhibit chemically induced neoplastic transformation in 10T1/2 cells. To address their mechanism of action, the effects of six diverse carotenoids, with or without provitamin A activity, on gap junctional communication and lipid peroxidation have been investigated. beta-Carotene, canthaxanthin, lutein, lycopene and alpha-carotene increased gap junctional intercellular communication in a dose-dependent manner in the above order of potency, whereas m-bixin was inactive at concentrations up to 10(-5) M. alpha-Tocopherol, a potent chain-breaking antioxidant, caused a marginal enhancement of junctional communication. The enhancement of junctional communication by diverse carotenoids showed a strong statistical correlation with their previously determined ability to inhibit methylcholanthrene-induced neoplastic transformation (r = -0.75). All carotenoids tested inhibited lipid peroxidation, but with differing potencies. alpha-Tocopherol was the most active inhibitor followed by m-bixin. The capacity of carotenoids or alpha-tocopherol to inhibit lipid peroxidation was neither consistent with their ability to inhibit neoplastic transformation (r = 0.30) nor to increase junctional communication (r = 0.12). Since junctional communication appears to play an important role in cell growth control and carcinogenesis, we propose that in this system carotenoid-enhanced intercellular communication provides a mechanistic basis for the cancer chemopreventive action of carotenoids. These data also imply that carotenoids function in a manner analogous to retinoids in the 10T1/2 assay system. Interestingly this activity appears independent of their provitamin A status. | lld:pubmed |
| pubmed-article:1934296 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1934296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1934296 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1934296 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:1934296 | pubmed:author | pubmed-author:BertramJ SJS | lld:pubmed |
| pubmed-article:1934296 | pubmed:author | pubmed-author:CooneyR VRV | lld:pubmed |
| pubmed-article:1934296 | pubmed:author | pubmed-author:ZhangL XLX | lld:pubmed |
| pubmed-article:1934296 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1934296 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1934296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1934296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1934296 | pubmed:pagination | 2109-14 | lld:pubmed |
| pubmed-article:1934296 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:meshHeading | pubmed-meshheading:1934296-... | lld:pubmed |
| pubmed-article:1934296 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1934296 | pubmed:articleTitle | Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. | lld:pubmed |
| pubmed-article:1934296 | pubmed:affiliation | Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813. | lld:pubmed |
| pubmed-article:1934296 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1934296 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1934296 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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