Linked Life Data

19342849

Source:http://linkedlifedata.com/resource/pubmed/id/19342849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-3
pubmed:abstractText
Among available treatments in the acute ischemic stroke, only intravenous thrombolysis has been demonstrated to be efficacious. Although the majority of pharmacological neuroprotectants have been efficacious in experimental studies, they have failed in clinical trials. Hence, we need to consider integrated cerebral protection which includes the concept of cerebral repair by supporting cerebral plasticity. We provide a nonsystematic review of the studies published on cerebral protection and repair treatments of cerebral ischemia considering the possibilities of stimulating brain plasticity by trophic factors and cell therapy. The majority of the neuroprotective drugs have failed in clinical trials. Citicoline shows a benefit in meta-analysis and it is currently being explored in a new trial (ICTUS). Neuroprotective drugs combined with reperfusion offer favorable results in experimental animals, but data from clinical studies are not enough. Repair therapies using cerebral plasticity stimulation (trophic factors) and cell therapy have shown certain efficacy in experimental and clinical studies and they are a developing route with clinical therapeutic perspectives.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1421-9786
pubmed:author
pubmed:copyrightInfo
(c) 2009 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
27 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-86
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cerebral protection, brain repair, plasticity and cell therapy in ischemic stroke.
pubmed:affiliation
Stroke Unit, Department of Neurology, La Paz University Hospital, Autónoma University of Madrid, Madrid, Spain.
pubmed:publicationType
Journal Article, Review