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pubmed:abstractText |
Activating mutations in genes KCNJ11 and ABCC8, which form the ATP-sensitive K+channel (K(ATP) channel), have been shown to cause transient or permanent neonatal diabetes. We describe here a rather different phenotype: two cases of adult diabetic patients-considered and treated as insulin-dependent diabetic patients since adolescence-who, in fact, turned out to be heterozygous for an ABCC8 mutation and able to successfully discontinue insulin while taking sulphonylurea treatment.
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pubmed:affiliation |
Endocrinology, Nutrition and Diabetes Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, 75651 Paris cedex 13, France. agnes.heurtier@psl.ap-hop-paris.fr
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