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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1991-11-25
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pubmed:abstractText |
A number of human hematopoietic growth factors have been genetically cloned and recombinant proteins produced. Several phase I and II clinical trials have already been published and results from phase III studies are becoming available. The use of erythropoietin to alleviate chemotherapy-induced myelosuppression is being tested. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have been extensively studied in patients receiving chemotherapy at standard or escalated doses and after bone marrow transplantation and appear to ameliorate chemotherapy-induced neutropenia and to speed bone marrow engraftment after high-dose cancer therapy. Interleukin-3 and interleukin-6 are quite early in their clinical development, but appear able to alleviate post-chemotherapy thrombocytopenia.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1040-8746
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
648-55
|
pubmed:dateRevised |
2005-11-16
|
pubmed:meshHeading |
pubmed-meshheading:1932223-Anemia,
pubmed-meshheading:1932223-Antineoplastic Agents,
pubmed-meshheading:1932223-Hematopoietic Cell Growth Factors,
pubmed-meshheading:1932223-Humans,
pubmed-meshheading:1932223-Infection,
pubmed-meshheading:1932223-Neoplasms,
pubmed-meshheading:1932223-Neutropenia,
pubmed-meshheading:1932223-Thrombocytopenia
|
pubmed:year |
1991
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pubmed:articleTitle |
Hematopoietic growth factors as supportive therapy for cancer- and chemotherapy-induced conditions.
|
pubmed:affiliation |
Catholic University of Louvain, Brussels, Belgium.
|
pubmed:publicationType |
Journal Article,
Review
|