rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
4
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pubmed:dateCreated |
1977-6-11
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pubmed:abstractText |
Six patients who took oral contraceptive agents for 5 to 18 years developed endometrial neoplasia. Endometrial adenocarcinoma occurred in 4 of these patients and severe adenomatous hyperplasia occured in 2. Five of the 6 patients took sequential agents; 1 patient used a combined agent. An additional patient who took Premarin and Provera sequentially developed adenocarcinoma of the endometrium. Eighteen cases of endometrial adenocarcinoma and 7 cases of adenomatous hyperplasia in patients with long-term sequential oral contraceptive use have previously been reported by others. Progestogens may not be completely protective against the endometrial cancer-causing potential of the estrogens, especially in the sequential regimens.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Sequential,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethisterone,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, Conjugated (USP),
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Medroxyprogesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Norgestrel
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0029-7844
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
390-2
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pubmed:dateRevised |
2009-10-26
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pubmed:meshHeading |
pubmed-meshheading:193073-Adenocarcinoma,
pubmed-meshheading:193073-Adult,
pubmed-meshheading:193073-Contraceptives, Oral,
pubmed-meshheading:193073-Contraceptives, Oral, Sequential,
pubmed-meshheading:193073-Contraceptives, Oral, Synthetic,
pubmed-meshheading:193073-Dimethisterone,
pubmed-meshheading:193073-Drug Combinations,
pubmed-meshheading:193073-Estrogens, Conjugated (USP),
pubmed-meshheading:193073-Ethinyl Estradiol,
pubmed-meshheading:193073-Female,
pubmed-meshheading:193073-Humans,
pubmed-meshheading:193073-Hyperplasia,
pubmed-meshheading:193073-Medroxyprogesterone,
pubmed-meshheading:193073-Middle Aged,
pubmed-meshheading:193073-Norgestrel,
pubmed-meshheading:193073-Time Factors,
pubmed-meshheading:193073-Uterine Neoplasms
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pubmed:year |
1977
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pubmed:articleTitle |
Endometrial carcinoma and oral contraceptive agents.
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pubmed:publicationType |
Journal Article
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