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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-4-8
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pubmed:abstractText |
Myostatin (Mstn) and growth/differentiation factor 11 (Gdf11) are highly related transforming growth factor beta (TGFbeta) family members that play important roles in regulating embryonic development and adult tissue homeostasis. Despite their high degree of sequence identity, targeted mutations in these genes result in non-overlapping phenotypes affecting distinct biological processes. Loss of Mstn in mice causes a doubling of skeletal muscle mass while loss of Gdf11 in mice causes dramatic anterior homeotic transformations of the axial skeleton, kidney agenesis, and an increase in progenitor cell number in several tissues. In order to investigate the possible functional redundancy of myostatin and Gdf11, we analyzed the effect of eliminating the functions of both of these signaling molecules.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-213X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:19298661-Animals,
pubmed-meshheading:19298661-Bone Development,
pubmed-meshheading:19298661-Bone Morphogenetic Proteins,
pubmed-meshheading:19298661-Female,
pubmed-meshheading:19298661-Gene Expression Regulation, Developmental,
pubmed-meshheading:19298661-Growth Differentiation Factors,
pubmed-meshheading:19298661-Male,
pubmed-meshheading:19298661-Mice,
pubmed-meshheading:19298661-Mice, Inbred C57BL,
pubmed-meshheading:19298661-Mice, Knockout,
pubmed-meshheading:19298661-Muscle, Skeletal,
pubmed-meshheading:19298661-Myostatin
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pubmed:year |
2009
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pubmed:articleTitle |
Redundancy of myostatin and growth/differentiation factor 11 function.
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pubmed:affiliation |
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. mcpherrona@niddk.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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