| pubmed-article:19282835 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19282835 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:19282835 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:19282835 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:19282835 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:19282835 | lifeskim:mentions | umls-concept:C0035020 | lld:lifeskim |
| pubmed-article:19282835 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:19282835 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19282835 | pubmed:dateCreated | 2009-8-12 | lld:pubmed |
| pubmed-article:19282835 | pubmed:abstractText | To evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/TCF3/PBX1, we analyzed 735 patients with B-cell precursor ALL treated in four successive protocols at St Jude Children's Research Hospital. The 41 patients with the t(1;19) had a comparable event-free survival to that of the 694 patients with other B-cell precursor ALL (P=0.63; 84.2+/-7.1% (s.e.) vs 84.0+/-1.8% at 5 years). However, patients with the t(1;19) had a lower cumulative incidence of any hematological relapse (P=0.06; 0 vs 8.3+/-1.2% at 5 years) but a significantly higher incidence of central nervous system (CNS) relapse (P<0.001; 9.0+/-5.1% vs 1.0+/-0.4% at 5 years). In a multivariate analysis, the t(1;19) was an independent risk factor for isolated CNS relapse. These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse. | lld:pubmed |
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| pubmed-article:19282835 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19282835 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19282835 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19282835 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19282835 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19282835 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19282835 | pubmed:issn | 1476-5551 | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:ChengCC | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:EvansW EWE | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:DowningJ RJR | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:RaimondiS CSC | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:RibeiroR CRC | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:CampanaDD | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:RellingM VMV | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:SandlundJ TJT | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:JehaSS | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:PeiDD | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:HowardS CSC | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:RubnitzJ EJE | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:OnciuMM | lld:pubmed |
| pubmed-article:19282835 | pubmed:author | pubmed-author:PuiC-HCH | lld:pubmed |
| pubmed-article:19282835 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19282835 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:19282835 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19282835 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19282835 | pubmed:pagination | 1406-9 | lld:pubmed |
| pubmed-article:19282835 | pubmed:dateRevised | 2011-2-24 | lld:pubmed |
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| pubmed-article:19282835 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19282835 | pubmed:articleTitle | Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1. | lld:pubmed |
| pubmed-article:19282835 | pubmed:affiliation | Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. | lld:pubmed |
| pubmed-article:19282835 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19282835 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19282835 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19282835 | lld:pubmed |
