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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-8-12
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pubmed:abstractText |
To evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/TCF3/PBX1, we analyzed 735 patients with B-cell precursor ALL treated in four successive protocols at St Jude Children's Research Hospital. The 41 patients with the t(1;19) had a comparable event-free survival to that of the 694 patients with other B-cell precursor ALL (P=0.63; 84.2+/-7.1% (s.e.) vs 84.0+/-1.8% at 5 years). However, patients with the t(1;19) had a lower cumulative incidence of any hematological relapse (P=0.06; 0 vs 8.3+/-1.2% at 5 years) but a significantly higher incidence of central nervous system (CNS) relapse (P<0.001; 9.0+/-5.1% vs 1.0+/-0.4% at 5 years). In a multivariate analysis, the t(1;19) was an independent risk factor for isolated CNS relapse. These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-12915598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-14559953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-14581336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-15071128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-15251979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-1593901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-16307026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-1670723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-18024406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-18308251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-2364165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-2939898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-3463388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-6607758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-7989935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-9469337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19282835-9657739
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1476-5551
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pubmed:author |
pubmed-author:CampanaDD,
pubmed-author:ChengCC,
pubmed-author:DowningJ RJR,
pubmed-author:EvansW EWE,
pubmed-author:HowardS CSC,
pubmed-author:JehaSS,
pubmed-author:OnciuMM,
pubmed-author:PeiDD,
pubmed-author:PuiC-HCH,
pubmed-author:RaimondiS CSC,
pubmed-author:RellingM VMV,
pubmed-author:RibeiroR CRC,
pubmed-author:RubnitzJ EJE,
pubmed-author:SandlundJ TJT
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1406-9
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pubmed:dateRevised |
2011-2-24
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pubmed:meshHeading |
pubmed-meshheading:19282835-Adolescent,
pubmed-meshheading:19282835-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19282835-Central Nervous System,
pubmed-meshheading:19282835-Child,
pubmed-meshheading:19282835-Child, Preschool,
pubmed-meshheading:19282835-Chromosomes, Human, Pair 1,
pubmed-meshheading:19282835-Chromosomes, Human, Pair 19,
pubmed-meshheading:19282835-Clinical Trials as Topic,
pubmed-meshheading:19282835-Combined Modality Therapy,
pubmed-meshheading:19282835-Cranial Irradiation,
pubmed-meshheading:19282835-Disease-Free Survival,
pubmed-meshheading:19282835-Female,
pubmed-meshheading:19282835-Genotype,
pubmed-meshheading:19282835-Humans,
pubmed-meshheading:19282835-Incidence,
pubmed-meshheading:19282835-Infant,
pubmed-meshheading:19282835-Injections, Spinal,
pubmed-meshheading:19282835-Leukemic Infiltration,
pubmed-meshheading:19282835-Male,
pubmed-meshheading:19282835-Oncogene Proteins, Fusion,
pubmed-meshheading:19282835-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19282835-Prognosis,
pubmed-meshheading:19282835-Proportional Hazards Models,
pubmed-meshheading:19282835-Risk,
pubmed-meshheading:19282835-Risk Assessment,
pubmed-meshheading:19282835-Translocation, Genetic,
pubmed-meshheading:19282835-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
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pubmed:affiliation |
Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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