Source:http://linkedlifedata.com/resource/pubmed/id/19282343
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2009-9-1
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pubmed:abstractText |
The present study verified the hypothesis that enhanced maturation of antigen-presenting CD11c(+) cells could explain the viral-induced exacerbated immune response to Saccharopolyspora rectivirgula (SR), the main antigen responsible for farmer's lung, a classic form of hypersensitivity pneumonitis (HP). Four groups of mice were studied: group 1 received intranasal instillations of saline; group 2 received instillations of SR for 12 weeks; group 3 received instillations of saline and a single infection with Sendai virus on week 3; and group 4 received instillations of SR for 12 weeks with a single administration of Sendai virus on week 3. On week 13, mice were sacrificed and bronchoalveolar lavage was performed. Lungs were harvested, digested with enzymes, and CD11c(+) cells were analysed in flow cytometry with anti-CD11c, anti-CD86 and anti-major histocompatibility complex class II markers. Immunofluorescence studies were also performed with the same cell surface markers. Both flow cytometry and immunofluorescence results demonstrate that mature CD11c(+) cells are significantly enhanced in SR-challenged mice simultaneously infected with Sendai virus, compared with other groups. These CD11c(+) cells persist in the lung for 9 weeks after the virus infection. Maturation of CD11c(+) cells could explain, at least in part, the virus-induced increased immune response to SR antigens in this model of HP, but mechanisms have still to be elucidated.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-D Antigens
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1399-3003
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
749-56
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pubmed:meshHeading |
pubmed-meshheading:19282343-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:19282343-Animals,
pubmed-meshheading:19282343-Antigens, Bacterial,
pubmed-meshheading:19282343-Antigens, CD11c,
pubmed-meshheading:19282343-Antigens, CD86,
pubmed-meshheading:19282343-Disease Models, Animal,
pubmed-meshheading:19282343-Female,
pubmed-meshheading:19282343-HLA-D Antigens,
pubmed-meshheading:19282343-Mice,
pubmed-meshheading:19282343-Mice, Inbred C57BL,
pubmed-meshheading:19282343-Respirovirus Infections,
pubmed-meshheading:19282343-Saccharopolyspora,
pubmed-meshheading:19282343-Sendai virus
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pubmed:year |
2009
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pubmed:articleTitle |
Mature CD11c(+) cells are enhanced in hypersensitivity pneumonitis.
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pubmed:affiliation |
Centre de recherche de l'Institute universitaire de cardiologie et de pneumologie de Québec, Quebec City, QC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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