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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-30
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pubmed:abstractText |
The stability of biapenem in aqueous solution was investigated. Forced degradation of biapenem was carried out under different concentrations, pH values and temperatures. The degradation products were determined by reverse-phase HPLC and identified by LC-MS/MS. One dimeric impurity was obtained by reverse-phase preparative HPLC and characterized by LC-MS/MS and NMR. A possible degradation mechanism has been presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1873-264X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
937-44
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pubmed:meshHeading |
pubmed-meshheading:19278804-Anti-Infective Agents,
pubmed-meshheading:19278804-Chromatography, High Pressure Liquid,
pubmed-meshheading:19278804-Drug Contamination,
pubmed-meshheading:19278804-Drug Stability,
pubmed-meshheading:19278804-Hydrogen-Ion Concentration,
pubmed-meshheading:19278804-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19278804-Mass Spectrometry,
pubmed-meshheading:19278804-Solutions,
pubmed-meshheading:19278804-Temperature,
pubmed-meshheading:19278804-Thienamycins,
pubmed-meshheading:19278804-Water
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pubmed:year |
2009
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pubmed:articleTitle |
The stability of biapenem and structural identification of impurities in aqueous solution.
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pubmed:affiliation |
Department of Pharmacy, Jiangsu Simcere Pharmaceutical R&D Co Ltd, Nanjing, PR China. xiaming1217@163.com
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pubmed:publicationType |
Journal Article
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