Linked Life Data

19278356

Source:http://linkedlifedata.com/resource/pubmed/id/19278356

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-3-12
pubmed:abstractText
Chen, Chi-Hsien, Yuh-Feng Liu, Shin-Da Lee, Wen-Chih Lee, Ying-Lan Tsai, Chien-Wen Hou, Chih-Yang Huang, and Chia-Hua Kuo. Altitude hypoxia increases glucose uptake in human heart. High Alt. Med Biol. 10:83-86, 2009.-Cardiac muscle is a highly oxygenated tissue that produces ATP mainly from fat oxidation. However, when the rate of oxygen demand exceeds oxygen supply, energy reliance on the carbohydrate substrate becomes crucial for sustaining normal cardiac function. In this study, the effect of acute altitude hypoxia on glucose uptake from circulation was determined, for the first time, in the human heart, using [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography (FDG-PET) in a simulated altitude condition (14% O(2), corresponding to approximately 3000 m above sea level) or room air (21% O(2)). Our results showed that subjects (n = 6) started to experience difficulty in sustaining the hypoxic condition at approximately 45 min. This was concurrent with a substantially increased blood lactate concentration, which reflects an accelerated rate of anaerobic glycolysis. Hypoxia elevated FDG uptake above control by approximately 70% in heart, but not in limbs (representing primarily skeletal muscle), brain, and liver. This study provides the first human evidence for the hypoxia-stimulated glucose uptake in heart. At this hypoxia level, the previously observed hypoxia-stimulated glucose uptake in rat skeletal muscle was not confirmed in the human study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1557-8682
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Altitude hypoxia increases glucose uptake in human heart.
pubmed:affiliation
Department of Physical Medicine and Rehabilitation, Taipei Medical University-Wan Fang Hospital, Taiwan.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't