Linked Life Data

19272678

Source:http://linkedlifedata.com/resource/pubmed/id/19272678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-5-18
pubmed:abstractText
A series of imidazole based compounds were synthesized by reacting simple imidazoles with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide (TBAB). The compounds bearing carbethoxy group undergo amidation with different amines in the presence of DBU to give respective carboxamides. The synthesized compounds were screened against Mycobacterium tuberculosis where compound 17 exhibited very good in vitro antitubercular activity and may serve as a lead for further optimization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1768-3254
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3350-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Synthesis and antitubercular screening of imidazole derivatives.
pubmed:affiliation
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't