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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-4
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pubmed:abstractText |
Acute lymphoblastic leukaemia (ALL) is the most common pediatric malignancy worldwide. The origin of this disease may be explained by a combination of genetic and environmental factors. Glutathione-s-transferases are a multi-gene family of enzymes involved in the detoxification of a wide variety of environmental carcinogens. A total of 92 immunophenotyped cases (below 25 years of age) and 150 cord blood controls were here analysed by PCR for GSTM1(Present/Null) and RQ-PCR allelic discrimination assay for GSTP1(Ile105Val). We found a significant increased risk for ALL with the GSTM1 null genotype (OR: 1.96, 95%CI=1.08-3.57), but no significant risk was found with the GSTP1 (Ile/Val) genotype (OR: 1.32, 95%CI = 0.74-2.37) and the GSTP1 Val/Val genotype (OR: 1.41, 95%CI=0.5-3.96) alone. Combined analysis of GSTM1 and GSTP1 showed significant higher risk associated with the GSTM1 (null/null) and GSTP1 [(Ile/Val)/ (Val/Val)] genotype (OR=2.78: 95%CI=1.16-6.69).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1513-7368
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-6
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pubmed:meshHeading |
pubmed-meshheading:19256768-Adolescent,
pubmed-meshheading:19256768-Age Distribution,
pubmed-meshheading:19256768-Case-Control Studies,
pubmed-meshheading:19256768-Chi-Square Distribution,
pubmed-meshheading:19256768-Child,
pubmed-meshheading:19256768-Child, Preschool,
pubmed-meshheading:19256768-Confidence Intervals,
pubmed-meshheading:19256768-Female,
pubmed-meshheading:19256768-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19256768-Genetic Predisposition to Disease,
pubmed-meshheading:19256768-Genotype,
pubmed-meshheading:19256768-Glutathione S-Transferase pi,
pubmed-meshheading:19256768-Glutathione Transferase,
pubmed-meshheading:19256768-Humans,
pubmed-meshheading:19256768-Incidence,
pubmed-meshheading:19256768-India,
pubmed-meshheading:19256768-Male,
pubmed-meshheading:19256768-Odds Ratio,
pubmed-meshheading:19256768-Polymerase Chain Reaction,
pubmed-meshheading:19256768-Polymorphism, Genetic,
pubmed-meshheading:19256768-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19256768-Probability,
pubmed-meshheading:19256768-Prognosis,
pubmed-meshheading:19256768-Risk Assessment,
pubmed-meshheading:19256768-Severity of Illness Index,
pubmed-meshheading:19256768-Sex Distribution,
pubmed-meshheading:19256768-Survival Analysis,
pubmed-meshheading:19256768-Young Adult
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pubmed:articleTitle |
Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population.
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pubmed:affiliation |
Dept of Molecular Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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