19255759

Source:http://linkedlifedata.com/resource/pubmed/id/19255759

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005528, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0242640, umls-concept:C0542341, umls-concept:C1541530, umls-concept:C1555029, umls-concept:C1698364, umls-concept:C2346567
pubmed:issue	5
pubmed:dateCreated	2009-8-18
pubmed:abstractText	Cediranib (recentin, AZD2171) is an oral small-molecule multiple receptor tyrosine kinases inhibitor. Here we investigate the ability of cediranib to reverse tumor multidrug resistance (MDR) due to overexpression of ABCB1 (P-glycoprotein) and ABCC1 (MRP1) transporters.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7806519
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/4-((4-Fluoro-2-methyl-1H-indol-5-yl)..., http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes, http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents, http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated..., http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein v-akt, http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/Rhodamine 123, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated..., http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1432-0843
pubmed:author	pubmed-author:ChenLi-MingLM, pubmed-author:DaiChun-LingCL, pubmed-author:FuLi-WuLW, pubmed-author:LiangYong-JuYJ, pubmed-author:TaoLi-YangLY, pubmed-author:WangFangF, pubmed-author:YanYan-YanYY
pubmed:issnType	Electronic
pubmed:volume	64
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	961-9
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:19255759-Adenosine Triphosphatases, pubmed-meshheading:19255759-Blotting, Western, pubmed-meshheading:19255759-Carrier Proteins, pubmed-meshheading:19255759-Cell Line, Tumor, pubmed-meshheading:19255759-Cell Proliferation, pubmed-meshheading:19255759-Drug Resistance, Multiple, pubmed-meshheading:19255759-Drug Resistance, Neoplasm, pubmed-meshheading:19255759-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:19255759-Flow Cytometry, pubmed-meshheading:19255759-Fluorescent Dyes, pubmed-meshheading:19255759-Humans, pubmed-meshheading:19255759-Indicators and Reagents, pubmed-meshheading:19255759-Multidrug Resistance-Associated Proteins, pubmed-meshheading:19255759-Oncogene Protein v-akt, pubmed-meshheading:19255759-P-Glycoprotein, pubmed-meshheading:19255759-Phosphorylation, pubmed-meshheading:19255759-Quinazolines, pubmed-meshheading:19255759-RNA Interference, pubmed-meshheading:19255759-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19255759-Rhodamine 123, pubmed-meshheading:19255759-Tetrazolium Salts, pubmed-meshheading:19255759-Thiazoles
pubmed:year	2009
pubmed:articleTitle	Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function.
pubmed:affiliation	State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't