Linked Life Data

19250609

Source:http://linkedlifedata.com/resource/pubmed/id/19250609

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-3-2
pubmed:abstractText
Peroxisome proliferator-activated receptor alpha and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E2, causing obesity in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1976-6696
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-5
pubmed:dateRevised
2009-4-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity.
pubmed:affiliation
Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't