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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-23
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pubmed:abstractText |
BAY 41-2272 (5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine) relaxes mesenteric arteries (MA) in a synergistic fashion with nitric oxide (NO). We hypothesized that the relaxation to BAY 41-2272 is decreased in spontaneously hypertensive rats (SHR) because of the reduced NO bioavailability in this strain and that relaxation would be improved by inhibiting the oxidative stress. We aimed to evaluate the influence of oxidative stress in BAY 41-2272-induced vasorelaxation in isolated MA from SHR.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-10488056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-10710123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-10769198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-10977868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-11181438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-11242081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-11606313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-12623955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-14519420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-15163558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-15655530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-15883232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-16173929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-16352702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-16391173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-17244722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-17339839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-1848694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-19387430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-2166511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-2488098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-8800570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19247264-9932481
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(4-Amino-5-cyclopropylpyrimidine-2...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetophenones,
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/SQ 29548,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/acetovanillone,
http://linkedlifedata.com/resource/pubmed/chemical/soluble guanylyl cyclase
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1941-7225
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-9
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:19247264-Acetophenones,
pubmed-meshheading:19247264-Acetylcholine,
pubmed-meshheading:19247264-Animals,
pubmed-meshheading:19247264-Antioxidants,
pubmed-meshheading:19247264-Cyclic GMP,
pubmed-meshheading:19247264-Endothelium, Vascular,
pubmed-meshheading:19247264-Enzyme Activation,
pubmed-meshheading:19247264-Guanylate Cyclase,
pubmed-meshheading:19247264-Hydrazines,
pubmed-meshheading:19247264-Nitric Oxide Synthase Type III,
pubmed-meshheading:19247264-Nitroprusside,
pubmed-meshheading:19247264-Oxidative Stress,
pubmed-meshheading:19247264-Pyrazoles,
pubmed-meshheading:19247264-Pyridines,
pubmed-meshheading:19247264-Rats,
pubmed-meshheading:19247264-Rats, Inbred SHR,
pubmed-meshheading:19247264-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:19247264-Superoxide Dismutase,
pubmed-meshheading:19247264-Vasodilation,
pubmed-meshheading:19247264-Vasodilator Agents
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pubmed:year |
2009
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pubmed:articleTitle |
Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats.
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pubmed:affiliation |
Department of Physical Education, Institute of Biosciences, São Paulo State University, UNESP, São Paulo, Brazil. fernanda.bmp@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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