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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-7-19
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pubmed:abstractText |
The pathogenesis of aortic valve stenosis may involve inflammation and we have previously demonstrated Chlamydophila pneumoniae (C. pneumoniae) DNA in stenotic aortic heart valves. Dissemination of these bacteria is probably mediated by alveolar macrophages. Bacterial DNA alone does not indicate whether the bacteria are viable and replicating. This study aimed to investigate the presence of C. pneumoniae mRNA, a marker of replicating bacteria, and C. pneumoniae DNA in stenotic aortic valves and the prevalence of C. pneumoniae in peripheral blood mononuclear cells (PBMC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1874-1754
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
143
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-62
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pubmed:meshHeading |
pubmed-meshheading:19246110-Adult,
pubmed-meshheading:19246110-Aged,
pubmed-meshheading:19246110-Aged, 80 and over,
pubmed-meshheading:19246110-Angina Pectoris,
pubmed-meshheading:19246110-Antibodies, Bacterial,
pubmed-meshheading:19246110-Aortic Valve,
pubmed-meshheading:19246110-Aortic Valve Stenosis,
pubmed-meshheading:19246110-Chlamydophila Infections,
pubmed-meshheading:19246110-Chlamydophila pneumoniae,
pubmed-meshheading:19246110-DNA, Bacterial,
pubmed-meshheading:19246110-Female,
pubmed-meshheading:19246110-Heart Valve Prosthesis,
pubmed-meshheading:19246110-Humans,
pubmed-meshheading:19246110-Immunoglobulin G,
pubmed-meshheading:19246110-Macrophages, Alveolar,
pubmed-meshheading:19246110-Male,
pubmed-meshheading:19246110-Middle Aged,
pubmed-meshheading:19246110-RNA, Bacterial,
pubmed-meshheading:19246110-RNA, Messenger,
pubmed-meshheading:19246110-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19246110-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Presence of Chlamydophila pneumoniae DNA but not mRNA in stenotic aortic heart valves.
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pubmed:affiliation |
Department of Medical Sciences, Infectious Diseases, Uppsala University Hospital, S-75185 Uppsala, Sweden. marie.edvinsson@medsci.uu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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