Source:http://linkedlifedata.com/resource/pubmed/id/19242345
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-3-25
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pubmed:abstractText |
In critically ill patients, preventing hyperglycemia (HG) with insulin therapy partially prevented organ dysfunction and protected mitochondria. A study in a rabbit model of critical illness indicated that lower blood glucose level, rather than higher insulinemia, is a key factor in such organ protection. In this model, we now investigated the impact of blood glucose lowering vs. hyperinsulinemia (HI) on mitochondria in relation to organ damage. We assessed whether such effects on mitochondria are mediated indirectly via organ perfusion or directly via reducing cellular glucose toxicity.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1530-0293
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1355-64
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pubmed:meshHeading |
pubmed-meshheading:19242345-Animals,
pubmed-meshheading:19242345-Blood Glucose,
pubmed-meshheading:19242345-Burns,
pubmed-meshheading:19242345-Critical Illness,
pubmed-meshheading:19242345-Disease Models, Animal,
pubmed-meshheading:19242345-Glucose,
pubmed-meshheading:19242345-Hyperglycemia,
pubmed-meshheading:19242345-Hyperinsulinism,
pubmed-meshheading:19242345-Male,
pubmed-meshheading:19242345-Mitochondria,
pubmed-meshheading:19242345-Rabbits
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pubmed:year |
2009
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pubmed:articleTitle |
Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness.
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pubmed:affiliation |
Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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