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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
Resistance to STI571 is an emerging problem for patients with chronic myelogenous leukemia (CML). Mutation in the kinase domain of Bcr-Abl is the predominant mechanism of the acquired resistance to STI571. In the present study, we investigated the effect of triptolide on cell survival or apoptosis in CML cells bearing Bcr-Abl-T315I or wild-type Bcr-Abl.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Epoxy Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib,
http://linkedlifedata.com/resource/pubmed/chemical/myeloid cell leukemia sequence 1...,
http://linkedlifedata.com/resource/pubmed/chemical/triptolide
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1686-97
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19240172-Adolescent,
pubmed-meshheading:19240172-Adult,
pubmed-meshheading:19240172-Aged,
pubmed-meshheading:19240172-Animals,
pubmed-meshheading:19240172-Antineoplastic Agents, Alkylating,
pubmed-meshheading:19240172-Apoptosis,
pubmed-meshheading:19240172-Blotting, Western,
pubmed-meshheading:19240172-Cell Cycle,
pubmed-meshheading:19240172-Cell Proliferation,
pubmed-meshheading:19240172-Diterpenes,
pubmed-meshheading:19240172-Drug Resistance, Neoplasm,
pubmed-meshheading:19240172-Epoxy Compounds,
pubmed-meshheading:19240172-Female,
pubmed-meshheading:19240172-Flow Cytometry,
pubmed-meshheading:19240172-Fusion Proteins, bcr-abl,
pubmed-meshheading:19240172-Humans,
pubmed-meshheading:19240172-Immunoenzyme Techniques,
pubmed-meshheading:19240172-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:19240172-Male,
pubmed-meshheading:19240172-Membrane Potential, Mitochondrial,
pubmed-meshheading:19240172-Mice,
pubmed-meshheading:19240172-Mice, Inbred BALB C,
pubmed-meshheading:19240172-Mice, Nude,
pubmed-meshheading:19240172-Middle Aged,
pubmed-meshheading:19240172-Mutation,
pubmed-meshheading:19240172-Phenanthrenes,
pubmed-meshheading:19240172-Piperazines,
pubmed-meshheading:19240172-Protein Kinase Inhibitors,
pubmed-meshheading:19240172-Protein-Tyrosine Kinases,
pubmed-meshheading:19240172-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19240172-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19240172-Pyrimidines,
pubmed-meshheading:19240172-RNA, Messenger,
pubmed-meshheading:19240172-Reactive Oxygen Species,
pubmed-meshheading:19240172-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19240172-Signal Transduction,
pubmed-meshheading:19240172-Transcription, Genetic,
pubmed-meshheading:19240172-Tripterygium,
pubmed-meshheading:19240172-Tumor Cells, Cultured,
pubmed-meshheading:19240172-Tumor Stem Cell Assay,
pubmed-meshheading:19240172-Xenograft Model Antitumor Assays,
pubmed-meshheading:19240172-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.
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pubmed:affiliation |
Department of Pathophysiology, Zhongshan School of Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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