rdf:type |
|
lifeskim:mentions |
umls-concept:C0015677,
umls-concept:C0023884,
umls-concept:C0086418,
umls-concept:C0205214,
umls-concept:C0205419,
umls-concept:C0332281,
umls-concept:C0456205,
umls-concept:C1097680,
umls-concept:C1540191,
umls-concept:C1550605,
umls-concept:C2700640
|
pubmed:issue |
6
|
pubmed:dateCreated |
2009-5-1
|
pubmed:abstractText |
It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepatic and adipose tissue insulin sensitivity; and (3) to investigate whether PNPLA3 expression is altered in the human fatty liver.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1432-0428
|
pubmed:author |
pubmed-author:ArkkilaPP,
pubmed-author:ArolaJJ,
pubmed-author:BergholmRR,
pubmed-author:EhrenborgEE,
pubmed-author:FisherR MRM,
pubmed-author:GroopLL,
pubmed-author:HamstenAA,
pubmed-author:JohanssonL ELE,
pubmed-author:JohanssonL MLM,
pubmed-author:KiviluotoTT,
pubmed-author:KotronenAA,
pubmed-author:Orho-MelanderMM,
pubmed-author:RidderstråleMM,
pubmed-author:RoosCC,
pubmed-author:WesterbackaJJ,
pubmed-author:Yki-JärvinenHH
|
pubmed:issnType |
Electronic
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1056-60
|
pubmed:meshHeading |
pubmed-meshheading:19224197-Adult,
pubmed-meshheading:19224197-Aged,
pubmed-meshheading:19224197-Body Mass Index,
pubmed-meshheading:19224197-Fatty Liver,
pubmed-meshheading:19224197-Female,
pubmed-meshheading:19224197-Genetic Predisposition to Disease,
pubmed-meshheading:19224197-Genotype,
pubmed-meshheading:19224197-Glucose Clamp Technique,
pubmed-meshheading:19224197-Humans,
pubmed-meshheading:19224197-Lipase,
pubmed-meshheading:19224197-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19224197-Male,
pubmed-meshheading:19224197-Membrane Proteins,
pubmed-meshheading:19224197-Middle Aged,
pubmed-meshheading:19224197-Obesity,
pubmed-meshheading:19224197-Polymerase Chain Reaction
|
pubmed:year |
2009
|
pubmed:articleTitle |
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
|
pubmed:affiliation |
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland. anna.kotronen@helsinki.fi
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|