Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-2-19
pubmed:abstractText
The present case-control study was to investigate the relationships of plasma leptin level and anthropometric measures of adiposity with the risk of breast cancer. Questionnaire information, anthropometric measures and blood samples were taken before treatment from 297 incident cases with breast cancer and 593 controls admitted for health examination at the Tri-Service General Hospital, Taipei, between 2004 and 2006. Plasma levels of leptin were measured by RIA. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for assessing the associations. Overall, higher leptin concentrations were significantly associated with an increased risk of breast cancer (OR (95% CI) for top vs bottom tertile of leptin was 1.63 (1.07-2.49), P(trend)=0.009). Waist circumference was a significant anthropometric factor for breast cancer in both pre- and postmenopausal women. Furthermore, the associations of leptin with breast cancer risk remained after adjustment for obesity indices. These results suggest that leptin may have an independent role in breast tumorigenesis. Regardless of the impact of circulating leptin, more research is needed to elucidate molecular mechanisms and local leptin levels that are critical for the development of breast cancers.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-10486426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-10719061, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-10877331, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-10997541, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-11438496, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-11472752, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-12054648, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-12441326, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-12687277, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-14985328, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15138597, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15156414, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15240518, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15313931, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15322511, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15522945, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15567935, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-15805581, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16011872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16019138, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16019366, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16110483, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16112274, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16533767, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-16752079, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-17377617, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-17716297, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-17908478, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-17914097, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-18004080, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-8180007, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-8665687, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-8781299, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-9264356, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-9291839, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-9504534, http://linkedlifedata.com/resource/pubmed/commentcorrection/19223908-9733517
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1532-1827
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
578-82
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Circulating levels of leptin, adiposity and breast cancer risk.
pubmed:affiliation
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't