Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-6-26
pubmed:abstractText
Despite their ability to cause septic shock and myocardial dysfunction, components of Gram-negative bacterial cell walls, like lipopolysaccharide, have been shown in numerous studies to induce myocardial protection during ischaemia-reperfusion injury. Muramyl dipeptide (MDP) is another such component recognized by an intracellular receptor, nucleotide-binding oligomerization domain 2. Receptor activation leads to intracellular signals through receptor interacting protein-2 (RIP2) and tumour growth factor-beta-activated kinase-1 (TAK1). However, little is known about the RIP2/TAK1 pathway in the heart. The aim of this study was to determine whether the RIP2/TAK1 pathway has a cardioprotective role in a mouse model of myocardial infarction.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-10802712, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-11502710, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-11842081, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-11894098, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-12056855, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-12829618, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-12835899, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-14962484, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-15059965, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-15464336, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-16183734, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-16249673, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-16875982, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-17348859, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-17693945, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-17698745, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18267957, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18310079, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18391174, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18400051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18490522, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18583716, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18586026, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-18617512, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-19011041, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-19038864, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-2648406, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-8394211, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-9346484, http://linkedlifedata.com/resource/pubmed/commentcorrection/19213760-9362258
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1755-3245
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-84
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:19213760-Acetylmuramyl-Alanyl-Isoglutamine, pubmed-meshheading:19213760-Animals, pubmed-meshheading:19213760-Cardiotonic Agents, pubmed-meshheading:19213760-Coronary Circulation, pubmed-meshheading:19213760-I-kappa B Proteins, pubmed-meshheading:19213760-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:19213760-MAP Kinase Kinase Kinases, pubmed-meshheading:19213760-Male, pubmed-meshheading:19213760-Mice, pubmed-meshheading:19213760-Mice, Inbred C57BL, pubmed-meshheading:19213760-Mice, Knockout, pubmed-meshheading:19213760-Myocardial Infarction, pubmed-meshheading:19213760-Myocardial Reperfusion Injury, pubmed-meshheading:19213760-Myocardium, pubmed-meshheading:19213760-NF-kappa B, pubmed-meshheading:19213760-Perfusion, pubmed-meshheading:19213760-Phosphorylation, pubmed-meshheading:19213760-Protein Kinase Inhibitors, pubmed-meshheading:19213760-Receptor-Interacting Protein Serine-Threonine Kinases, pubmed-meshheading:19213760-Signal Transduction, pubmed-meshheading:19213760-Ventricular Function, Left, pubmed-meshheading:19213760-Ventricular Pressure
pubmed:year
2009
pubmed:articleTitle
Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1.
pubmed:affiliation
King's College London British Heart Foundation Centre of Research Excellence, The Cardiovascular Division, The Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't