Linked Life Data

19204325

Source:http://linkedlifedata.com/resource/pubmed/id/19204325

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2009-5-8
pubmed:abstractText
We recently isolated a novel angiogenesis inhibitor, vasohibin-1, and its homologue, vasohibin-2. In this study we characterize the role of these 2 molecules in the regulation of angiogenesis. In a mouse model of subcutaneous angiogenesis, the expression of endogenous vasohibin-1 was low in proliferating ECs at the sprouting front but high in nonproliferating endothelial cells (ECs) in the termination zone. In contrast, endogenous vasohibin-2 was preferentially expressed in mononuclear cells mobilized from bone marrow that infiltrated the sprouting front. When applied exogenously, vasohibin-1 inhibited angiogenesis at the sprouting front where endogenous vasohibin-1 was scarce but did not influence vascularity in the termination zone where endogenous vasohibin-1 was enriched. Exogenous vasohibin-2 prevented the termination of angiogenesis in the termination zone and increased vascularity in this region. Angiogenesis was persistent in the termination zone in the vasohibin-1 knockout mice, whereas angiogenesis was deficient at the sprouting front in the vasohibin-2 knockout mice. Supplementation of deficient proteins normalized the abnormal patterns of angiogenesis in the vasohibin knockout mice. These results indicate that vasohibin-1 is expressed in ECs in the termination zone to halt angiogenesis, whereas vasohibin-2 is expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4810-8
pubmed:meshHeading
pubmed-meshheading:19204325-Adenoviridae, pubmed-meshheading:19204325-Animals, pubmed-meshheading:19204325-Blotting, Northern, pubmed-meshheading:19204325-Cell Cycle Proteins, pubmed-meshheading:19204325-Endothelial Cells, pubmed-meshheading:19204325-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:19204325-Female, pubmed-meshheading:19204325-Immunoenzyme Techniques, pubmed-meshheading:19204325-Male, pubmed-meshheading:19204325-Mice, pubmed-meshheading:19204325-Mice, Inbred C57BL, pubmed-meshheading:19204325-Mice, Knockout, pubmed-meshheading:19204325-Neovascularization, Pathologic, pubmed-meshheading:19204325-Neovascularization, Physiologic, pubmed-meshheading:19204325-RNA, Messenger, pubmed-meshheading:19204325-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19204325-Skin
pubmed:year
2009
pubmed:articleTitle
Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis.
pubmed:affiliation
Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't