Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-2-25
pubmed:abstractText
The histone H3 demethylase Not dead yet-1 (Ndy1/KDM2B) is a physiological inhibitor of senescence. Here, we show that Ndy1 is down-regulated during senescence in mouse embryonic fibroblasts (MEFs) and that it represses the Ink4a/Arf locus. Ndy1 counteracts the senescence-associated down-regulation of Ezh2, a component of polycomb-repressive complex (PRC) 2, via a JmjC domain-dependent process leading to the global and Ink4a/Arf locus-specific up-regulation of histone H3K27 trimethylation. The latter promotes the Ink4a/Arf locus-specific binding of Bmi1, a component of PRC1. Ndy1, which interacts with Ezh2, also binds the Ink4a/Arf locus and demethylates the locus-associated histone H3K36me2 and histone H3K4me3. The combination of histone modifications driven by Ndy1 interferes with the binding of RNA Polymerase II, resulting in the transcriptional silencing of the Ink4a/Arf locus and contributing to the Ndy1 immortalization phenotype. Other studies show that, in addition to inhibiting replicative senescence, Ndy1 inhibits Ras oncogene-induced senescence via a similar molecular mechanism.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-11544531, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-12065407, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-12351676, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-12667454, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-14595015, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-14647293, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-15196462, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-15231737, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-15680324, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-15988478, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16227595, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16286008, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16293602, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16314526, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16362057, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16364921, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16503129, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16618801, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16756492, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16921403, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-16943429, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17060944, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17158930, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17173055, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17296600, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17332741, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17344414, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17410184, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17512414, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17525233, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17545470, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17589523, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17662938, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17884155, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17974970, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-17994099, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-18007591, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-18206970, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-18250326, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-18838535, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-8620534, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-9393858, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-9765203, http://linkedlifedata.com/resource/pubmed/commentcorrection/19202064-9923679
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2641-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...