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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-3
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pubmed:abstractText |
Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insights into tumorigenesis. To identify new genes controlling the senescence programme, we performed a loss-of-function genetic screen in primary human fibroblasts. We report that knockdown of the M-type receptor PLA2R (phospholipase A2 receptor) prevents the onset of replicative senescence and diminishes stress-induced senescence. Interestingly, expression of PLA2R increases during replicative senescence, and its ectopic expression results in premature senescence. We show that PLA2R regulates senescence in a reactive oxygen species-DNA damage-p53-dependent manner. Taken together, our study identifies PLA2R as a potential new tumour suppressor gene crucial in the induction of cellular senescence through the activation of the p53 pathway.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19197340-10066760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19197340-10075689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19197340-10910364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19197340-10946309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19197340-11698192,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1469-3178
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-7
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
pubmed-meshheading:19197340-Animals,
pubmed-meshheading:19197340-Cell Aging,
pubmed-meshheading:19197340-Cell Line,
pubmed-meshheading:19197340-Down-Regulation,
pubmed-meshheading:19197340-Fibroblasts,
pubmed-meshheading:19197340-Gene Knockdown Techniques,
pubmed-meshheading:19197340-Humans,
pubmed-meshheading:19197340-Reactive Oxygen Species,
pubmed-meshheading:19197340-Receptors, Phospholipase A2,
pubmed-meshheading:19197340-Signal Transduction,
pubmed-meshheading:19197340-Tumor Suppressor Protein p53
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pubmed:year |
2009
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pubmed:articleTitle |
The M-type receptor PLA2R regulates senescence through the p53 pathway.
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pubmed:affiliation |
UMR 8161, Institut de Biologie de Lille, CNRS/Universités de Lille 1 et 2/Institut Pasteur de Lille, IFR 142, 59021 Lille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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