19194166

Source:http://linkedlifedata.com/resource/pubmed/id/19194166

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001640, umls-concept:C0002766, umls-concept:C0205210, umls-concept:C1149516, umls-concept:C1332027
pubmed:issue	2
pubmed:dateCreated	2009-2-5
pubmed:abstractText	The use of alpha-2 adrenergic agonists for analgesia is limited due to a narrow therapeutic window. Definition of the role of alpha receptor subtypes in alpha agonist mediated analgesia may identify strategies to separate the analgesic from sedative and cardiovascular effects.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/1300217
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Clonidine, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists, http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate, http://linkedlifedata.com/resource/pubmed/chemical/Prazosin, http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2, http://linkedlifedata.com/resource/pubmed/chemical/brimonidine, http://linkedlifedata.com/resource/pubmed/chemical/sulprostone, http://linkedlifedata.com/resource/pubmed/chemical/tizanidine
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1528-1175
pubmed:author	pubmed-author:CheeversCynthia VCV, pubmed-author:DonelloJohn EJE, pubmed-author:GilDaniel WDW, pubmed-author:KedzieKaren MKM, pubmed-author:ManlapazCynthia ACA, pubmed-author:RaoSandhyaS, pubmed-author:TangElaineE
pubmed:issnType	Electronic
pubmed:volume	110
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	401-7
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:19194166-Adrenergic alpha-1 Receptor Agonists, pubmed-meshheading:19194166-Adrenergic alpha-Agonists, pubmed-meshheading:19194166-Adrenergic alpha-Antagonists, pubmed-meshheading:19194166-Analgesics, pubmed-meshheading:19194166-Animals, pubmed-meshheading:19194166-Calcium, pubmed-meshheading:19194166-Clonidine, pubmed-meshheading:19194166-Dinoprostone, pubmed-meshheading:19194166-Drug Interactions, pubmed-meshheading:19194166-Excitatory Amino Acid Agonists, pubmed-meshheading:19194166-Exploratory Behavior, pubmed-meshheading:19194166-Hyperalgesia, pubmed-meshheading:19194166-Injections, Spinal, pubmed-meshheading:19194166-Mice, pubmed-meshheading:19194166-Mice, Inbred C57BL, pubmed-meshheading:19194166-Mice, Knockout, pubmed-meshheading:19194166-N-Methylaspartate, pubmed-meshheading:19194166-Pain Measurement, pubmed-meshheading:19194166-Prazosin, pubmed-meshheading:19194166-Quinoxalines, pubmed-meshheading:19194166-Receptors, Adrenergic, alpha-2
pubmed:year	2009
pubmed:articleTitle	Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.
pubmed:affiliation	Department of Biological Sciences, Allergan, Inc., Irvine, California 92612, USA. Gil_daniel@allergan.com
pubmed:publicationType	Journal Article