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rdf:type |
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lifeskim:mentions |
umls-concept:C0018802,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0032173,
umls-concept:C0034693,
umls-concept:C0040649,
umls-concept:C0086222,
umls-concept:C0205082,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0907532,
umls-concept:C1705733
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pubmed:issue |
4
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|
pubmed:dateCreated |
2009-3-30
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pubmed:abstractText |
Increased risk of thrombo-embolic events in congestive heart failure (CHF) has been attributed to a hypercoagulable state including vascular endothelial dysfunction and reduced bioavailability of nitric oxide (NO) as well as platelet activation. We investigated whether treatment with a novel endothelial NO synthase (eNOS)-transcription enhancer positively modulates systemic NO bioavailability and reduces platelet activation in rats with CHF.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1388-9842
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
336-41
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pubmed:dateRevised |
2011-6-8
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pubmed:meshHeading |
pubmed-meshheading:19193626-Animals,
pubmed-meshheading:19193626-Benzamides,
pubmed-meshheading:19193626-Blood Platelets,
pubmed-meshheading:19193626-Blood Proteins,
pubmed-meshheading:19193626-Cell Adhesion Molecules,
pubmed-meshheading:19193626-Disease Models, Animal,
pubmed-meshheading:19193626-Dose-Response Relationship, Drug,
pubmed-meshheading:19193626-Heart Failure,
pubmed-meshheading:19193626-Male,
pubmed-meshheading:19193626-Microfilament Proteins,
pubmed-meshheading:19193626-Nitric Oxide,
pubmed-meshheading:19193626-Phosphoproteins,
pubmed-meshheading:19193626-Phosphorylation,
pubmed-meshheading:19193626-Platelet Activation,
pubmed-meshheading:19193626-Rats,
pubmed-meshheading:19193626-Rats, Wistar,
pubmed-meshheading:19193626-Severity of Illness Index,
pubmed-meshheading:19193626-Treatment Outcome,
pubmed-meshheading:19193626-Vasoconstriction
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer.
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pubmed:affiliation |
Medizinische Klinik und Poliklinik I, Julius-Maximilians-Universität Würzburg, Josef Schneider Strasse 2, 97080 Würzburg, Germany. a.schaefer@medizin.uni-wuerzburg.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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