Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-2-3
pubmed:abstractText
We detect internal water molecules in a membrane-embedded receptor-transducer complex and demonstrate water structure changes during formation of the signaling state. Time-resolved FTIR spectroscopy reveals stimulus-induced repositioning of one or more structurally active water molecules to a significantly more hydrophobic environment in the signaling state of the sensory rhodopsin II (SRII)-transducer (HtrII) complex. These waters, distinct from bound water molecules within the SRII receptor, appear to be in the middle of the transmembrane interface region near the Tyr199(SRII)-Asn74(HtrII) hydrogen bond. We conclude that water potentially plays an important role in the SRII --> HtrII signal transfer mechanism in the membrane's hydrophobic core.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-11747445, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-12368857, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-15951432, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-16280982, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-16452929, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-17005405, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-17050685, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-17438299, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-17898961, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-17986191, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-18346091, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-18441234, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-18480818, http://linkedlifedata.com/resource/pubmed/commentcorrection/19187030-9241419
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1520-4995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-3
pubmed:dateRevised
2011-4-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Active water in protein-protein communication within the membrane: the case of SRII-HtrII signal relay.
pubmed:affiliation
Department of Physics, Molecular Biophysics Laboratory, and Center for Photonics, Boston University, Boston, Massachusetts 02215, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural