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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-2-27
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pubmed:abstractText |
The regenerative process in the pancreas is of particular interest, since insulin-producing beta cells are lost in diabetes. Differentiation of new beta cells from pancreatic non-endocrine cells has been reported in vivo and in vitro, a finding that implies the existence of pancreatic stem/progenitor cells. However, while tissue-specific stem cells are well documented in skin, intestine and testis, pancreatic stem cells have been elusive. We hypothesised that pancreatic stem/progenitor cells within the non-endocrine fraction could be a source of new islets in vitro.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1432-0428
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
645-52
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19183938-Animals,
pubmed-meshheading:19183938-Cell Culture Techniques,
pubmed-meshheading:19183938-Cell Separation,
pubmed-meshheading:19183938-Diabetes Mellitus, Type 1,
pubmed-meshheading:19183938-Flow Cytometry,
pubmed-meshheading:19183938-Genes, Reporter,
pubmed-meshheading:19183938-Green Fluorescent Proteins,
pubmed-meshheading:19183938-Insulin,
pubmed-meshheading:19183938-Insulin-Secreting Cells,
pubmed-meshheading:19183938-Islets of Langerhans,
pubmed-meshheading:19183938-Mice,
pubmed-meshheading:19183938-Mice, Inbred C57BL,
pubmed-meshheading:19183938-Mice, Transgenic,
pubmed-meshheading:19183938-Pancreas,
pubmed-meshheading:19183938-Pancreatic Ducts,
pubmed-meshheading:19183938-Promoter Regions, Genetic,
pubmed-meshheading:19183938-RNA, Messenger,
pubmed-meshheading:19183938-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2009
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pubmed:articleTitle |
Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse.
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pubmed:affiliation |
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, 1 Joslin Place, Boston, MA, 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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