Linked Life Data

1917518

Source:http://linkedlifedata.com/resource/pubmed/id/1917518

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pubmed-article:1917518pubmed:abstractTextThe 323/A3 murine monoclonal antibody, initially described as reactive to breast carcinomas, is found by immunohistological analyses to have broad cross reactivity with adenocarcinomas of diverse histologic origin. The 323/A3 antigen is similar to the tumor-associated 17-1A antigen as revealed by immunoblot and cross-competition cell binding studies. We have investigated the potential use of the 323/A3 monoclonal antibody for tumor imaging as a Fab' molecule labeled with 99mTc. In vitro studies demonstrate that 323/A3 Fab' has high affinity (2-3 x 10(9) M-1) with no significant loss of immunoreactivity compared to the intact IgG. In vivo studies demonstrate that 99mTc 323/A3 Fab' can rapidly detect human breast and colon tumor xenografts growing in athymic nude mice. Distinct breast tumor visualization is observed as early as 1 h post intravenous administration with the 99mTc 323/A3 Fab'. Distinct colon tumor visualization is observed by 3 h (the earliest time point imaged). Tumor-to-blood ratios are higher for 99mTc 323/A3 Fab' than with a 99mTc-labeled nonspecific isotype-matched Fab' antibody. These results suggest that 99mTc 323/A3 Fab' can detect 17-1A antigen and may have potential clinical utility for the rapid diagnostic imaging of adenocarcinomas.lld:pubmed
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pubmed-article:1917518pubmed:dateRevised2008-2-21lld:pubmed
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pubmed-article:1917518pubmed:year1991lld:pubmed
pubmed-article:1917518pubmed:articleTitleEvaluation of the 323/A3 monoclonal antibody and the use of technetium-99m-labeled 323/A3 Fab' for the detection of pan adenocarcinoma.lld:pubmed
pubmed-article:1917518pubmed:affiliationResearch and Development Division, Centocor, Inc., Malvern, PA 19355.lld:pubmed
pubmed-article:1917518pubmed:publicationTypeJournal Articlelld:pubmed
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