Linked Life Data

19175015

Source:http://linkedlifedata.com/resource/pubmed/id/19175015

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-29
pubmed:abstractText
The gender aspect in pharmacokinetics and pharmacodynamics of anesthetics has attracted little attention. Knowledge of previous work is required to decide if gender-based differences in clinical is justified. Females have 20-30% greater sensitivity to the muscle relaxant effects of vecuronium and rocuronium. When rapid onset of or short duration of action is very important, gender-modified dosing may be considered. Males are more sensitive than females to propofol. It may therefore be necessary to decrease the propofol dose by 30-40% in males compared with females in order to achieve similar recovery times. Females are more sensitive than males to opioid receptor agonists, as shown for morphine as well as for pentazocin. On the other hand, females may experience respiratory depression and other adverse effects more easily if they are given the same doses as males. These examples illustrate that gender should be taken into account as a factor that may be predictive for the dosage of several anesthetic drugs. Moreover, there is an obvious need for more research in this area in order to further optimize drug treatment in anesthesia.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-4892
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Gender differences in pharmacokinetics of anesthetics].
pubmed:affiliation
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8677.
pubmed:publicationType
Journal Article, English Abstract, Review