| pubmed-article:19168951 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0029341 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0032285 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C1522053 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19168951 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19168951 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19168951 | pubmed:dateCreated | 2009-1-26 | lld:pubmed |
| pubmed-article:19168951 | pubmed:abstractText | Platelet-activating factor (PAF) is a critical mediator of severe inflammatory diseases such as pneumonia, and the PAF-receptor (PAFR) is known to be an anchor for Streptococcus pneumoniae attachment to lung epithelial cells. We conducted a DNA microarray analysis to detect critical factors that mediate fulminant pneumonia due to influenza virus and S. pneumoniae co-infection in mice. Among the factors detected, levels of PAF-acetyl hydrolase (PAF-AH), which functions as inactivated PAF, were significantly increased, and PAFR was expressed in co-infected mouse lungs, as compared to the respective levels in mice infected with either S. pneumoniae or virus alone. Significantly elevated PAF-AH enzymatic activity was observed in the co-infected mouse lung, suggesting that co-infection activated PAF-related factors. These findings suggest that PAF and related molecules play important roles in fulminant pneumonia due to influenza virus infection, especially when severe bacterial pneumonia is complicated by co-infection with influenza virus. | lld:pubmed |
| pubmed-article:19168951 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19168951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19168951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19168951 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19168951 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19168951 | pubmed:issn | 1344-6304 | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:KohnoShigeruS | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:YamamotoYoshi... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:MukaeHiroshiH | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:SekiMasafumiM | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:YanagiharaKat... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:ImamuraYoshif... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:MiyazakiYoshi... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:IzumikawaKoic... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:NakamuraShige... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:TashiroTakayo... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:KakeyaHiroshi... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:HaraAtsukoA | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:KuriharaShint... | lld:pubmed |
| pubmed-article:19168951 | pubmed:author | pubmed-author:KosaiKosukeK | lld:pubmed |
| pubmed-article:19168951 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19168951 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:19168951 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19168951 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19168951 | pubmed:pagination | 6-10 | lld:pubmed |
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| pubmed-article:19168951 | pubmed:meshHeading | pubmed-meshheading:19168951... | lld:pubmed |
| pubmed-article:19168951 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19168951 | pubmed:articleTitle | Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection. | lld:pubmed |
| pubmed-article:19168951 | pubmed:affiliation | Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan. seki@nagasaki-u.ac.jp | lld:pubmed |
| pubmed-article:19168951 | pubmed:publicationType | Journal Article | lld:pubmed |
