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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0029341,
umls-concept:C0032285,
umls-concept:C0185117,
umls-concept:C0205082,
umls-concept:C0521009,
umls-concept:C0567416,
umls-concept:C0678226,
umls-concept:C1522053,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-26
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pubmed:abstractText |
Platelet-activating factor (PAF) is a critical mediator of severe inflammatory diseases such as pneumonia, and the PAF-receptor (PAFR) is known to be an anchor for Streptococcus pneumoniae attachment to lung epithelial cells. We conducted a DNA microarray analysis to detect critical factors that mediate fulminant pneumonia due to influenza virus and S. pneumoniae co-infection in mice. Among the factors detected, levels of PAF-acetyl hydrolase (PAF-AH), which functions as inactivated PAF, were significantly increased, and PAFR was expressed in co-infected mouse lungs, as compared to the respective levels in mice infected with either S. pneumoniae or virus alone. Significantly elevated PAF-AH enzymatic activity was observed in the co-infected mouse lung, suggesting that co-infection activated PAF-related factors. These findings suggest that PAF and related molecules play important roles in fulminant pneumonia due to influenza virus infection, especially when severe bacterial pneumonia is complicated by co-infection with influenza virus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1344-6304
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pubmed:author |
pubmed-author:HaraAtsukoA,
pubmed-author:ImamuraYoshifumiY,
pubmed-author:IzumikawaKoichiK,
pubmed-author:KakeyaHiroshiH,
pubmed-author:KohnoShigeruS,
pubmed-author:KosaiKosukeK,
pubmed-author:KuriharaShintaroS,
pubmed-author:MiyazakiYoshitsuguY,
pubmed-author:MukaeHiroshiH,
pubmed-author:NakamuraShigekiS,
pubmed-author:SekiMasafumiM,
pubmed-author:TashiroTakayoshiT,
pubmed-author:YamamotoYoshihiroY,
pubmed-author:YanagiharaKatsunoriK
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6-10
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pubmed:meshHeading |
pubmed-meshheading:19168951-1-Alkyl-2-acetylglycerophosphocholine Esterase,
pubmed-meshheading:19168951-Animals,
pubmed-meshheading:19168951-Blotting, Western,
pubmed-meshheading:19168951-Influenza A Virus, H1N1 Subtype,
pubmed-meshheading:19168951-Male,
pubmed-meshheading:19168951-Mice,
pubmed-meshheading:19168951-Mice, Inbred CBA,
pubmed-meshheading:19168951-Microarray Analysis,
pubmed-meshheading:19168951-Orthomyxoviridae Infections,
pubmed-meshheading:19168951-Platelet Activating Factor,
pubmed-meshheading:19168951-Platelet Membrane Glycoproteins,
pubmed-meshheading:19168951-Pneumonia,
pubmed-meshheading:19168951-Polymerase Chain Reaction,
pubmed-meshheading:19168951-RNA, Messenger,
pubmed-meshheading:19168951-Receptors, G-Protein-Coupled,
pubmed-meshheading:19168951-Reverse Transcription,
pubmed-meshheading:19168951-Streptococcus pneumoniae
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pubmed:year |
2009
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pubmed:articleTitle |
Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.
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pubmed:affiliation |
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan. seki@nagasaki-u.ac.jp
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pubmed:publicationType |
Journal Article
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