|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2009-2-23
|
|
pubmed:abstractText |
Succinic semialdehyde dehydrogenase (SSADH) deficiency is an inborn error of GABA metabolism characterized clinically by ataxia, psychomotor retardation and seizures. A mouse model of SSADH deficiency, the Aldh5a1(-/-) mouse, has been used to study the pathophysiology and treatment of this disorder. Recent work from our group has shown that the ketogenic diet (KD) is effective in normalizing the Aldh5a1(-/-) phenotype, although the mechanism of the effect remains unclear.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-10762371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-11080246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-11544478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-14769485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-14769489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-15582027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-16203683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-16240371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-16257638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-16807920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-17303287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-17854388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-18199435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-4525180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-7628735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-9578039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19168117-9744941
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0006-3002
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
1790
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
208-12
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:19168117-Adenosine Triphosphate,
pubmed-meshheading:19168117-Animals,
pubmed-meshheading:19168117-Brain,
pubmed-meshheading:19168117-Calibration,
pubmed-meshheading:19168117-Ketogenic Diet,
pubmed-meshheading:19168117-Mice,
pubmed-meshheading:19168117-Mice, Knockout,
pubmed-meshheading:19168117-Microscopy, Electron, Transmission,
pubmed-meshheading:19168117-Mitochondria,
pubmed-meshheading:19168117-Succinate-Semialdehyde Dehydrogenase
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1(-/-) mice.
|
|
pubmed:affiliation |
Neuroscience and Mental Health, 6535 Hill Wing, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8. kirk.nylen@utoronto.ca
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
