Linked Life Data

19160667

Source:http://linkedlifedata.com/resource/pubmed/id/19160667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-1-23
pubmed:abstractText
Lipids in biological membranes are asymmetrically distributed across the bilayer. The choline-containing lipids, phosphatidylcholine (PtdCho) and sphingomyelin (SM), are more abundant in the external leaflet. In contrast, the amino-containing glycerophospholipids, phosphatidylserine (PtdSer) and phosphatidylethanolamine (PtdEth), are located preferentially on the cytoplasmic leaflet. The maintenance of transbilayer lipid asymmetry is essential for normal membrane function, and disruption of this asymmetry is associated with cell activation or pathological condition. The physiological role of ceramide formation in response to cell stimulation remains controversial. Ceramide formation serves many different functions at various locations in the cell. Despite the limited capacity for spontaneous intracellular diffusion or membrane flip-flop of lipids in membranes, we have found that ceramide production, via sphingomyelinase action or addition of external ceramide, induces the transbilayer lipid motion of the lipids within the cellular membrane. This chapter outlines various commonly used assays for measuring lipid flip-flop induced by ceramide in cell and model membranes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
462
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-65
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Ceramide-induced transbilayer (flip-flop) lipid movement in membranes.
pubmed:affiliation
CSIC and University of the Basque Country, Bilbao, Spain.
pubmed:publicationType
Journal Article