rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-22
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pubmed:abstractText |
Dementia can be caused by different diseases including Alzheimer's disease (AD), dementia with Lewy bodies (DLB), or both (AD + DLB). University of Kentucky AD Center pathologically-diagnosed AD and AD + DLB cases were evaluated who had three or more longitudinal antemortem mental status examinations (n = 156). Patients with important concomitant pathology (n = 5) or patients that were profoundly demented at recruitment (intake MMSE < 20; n = 86) were excluded to strengthen our ability to test the association of specific clinical and pathological indices. Patients with pathologically-diagnosed AD + DLB (n = 25) lost cognitive capacity faster than patients with AD alone (n = 40). In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-10844722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-10984725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-11217870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-11255450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-11723339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-12489913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-12754338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-1512391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-15985574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-16380608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-16401735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-16858742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-17159097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-17265415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-17727648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-18090922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-18289452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-9330994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-9710002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158418-9785144
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1387-2877
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-34
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pubmed:dateRevised |
2011-8-31
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pubmed:meshHeading |
pubmed-meshheading:19158418-Aged,
pubmed-meshheading:19158418-Alzheimer Disease,
pubmed-meshheading:19158418-Cholinesterase Inhibitors,
pubmed-meshheading:19158418-Cognition,
pubmed-meshheading:19158418-Cognition Disorders,
pubmed-meshheading:19158418-Databases, Factual,
pubmed-meshheading:19158418-Disease Progression,
pubmed-meshheading:19158418-Female,
pubmed-meshheading:19158418-Humans,
pubmed-meshheading:19158418-Logistic Models,
pubmed-meshheading:19158418-Longitudinal Studies,
pubmed-meshheading:19158418-Male,
pubmed-meshheading:19158418-Models, Statistical,
pubmed-meshheading:19158418-Neuropsychological Tests
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pubmed:year |
2009
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pubmed:articleTitle |
Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB.
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pubmed:affiliation |
Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY, USA. pnels2@email.uky.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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