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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-12
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pubmed:abstractText |
The aim of this study was to compare amprenavir pharmacokinetics in HIV/hepatitis C virus (HCV)-co-infected cirrhotic patients receiving non-boosted fosamprenavir 700 mg twice daily with HCV/HIV-co-infected non-cirrhotic subjects and HIV-mono-infected subjects receiving fosamprenavir/ritonavir 700/100 mg twice daily. Liver stiffness at baseline and alanine aminotransferase levels at baseline and during follow-up were measured in order to find a correlation between drug levels and liver fibrosis or hepatotoxicity.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1460-2091
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pubmed:author |
pubmed-author:BonoraStefanoS,
pubmed-author:CarosiGiampieroG,
pubmed-author:GattiFrancescaF,
pubmed-author:LoregianAriannaA,
pubmed-author:MattiAlessandroA,
pubmed-author:NastaPaolaP,
pubmed-author:PagniSilvanaS,
pubmed-author:PalùGiorgioG,
pubmed-author:ParisiSaverio GSG,
pubmed-author:PrestiniKatielaK,
pubmed-author:PuotiMassimoM,
pubmed-author:de RequenaDaniel GonzalezDG
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
575-8
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pubmed:dateRevised |
2009-6-9
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pubmed:meshHeading |
pubmed-meshheading:19151039-Adult,
pubmed-meshheading:19151039-Alanine Transaminase,
pubmed-meshheading:19151039-Anti-HIV Agents,
pubmed-meshheading:19151039-Carbamates,
pubmed-meshheading:19151039-Chromatography, High Pressure Liquid,
pubmed-meshheading:19151039-Elasticity Imaging Techniques,
pubmed-meshheading:19151039-Female,
pubmed-meshheading:19151039-HIV,
pubmed-meshheading:19151039-HIV Infections,
pubmed-meshheading:19151039-Hepatitis C,
pubmed-meshheading:19151039-Humans,
pubmed-meshheading:19151039-Liver,
pubmed-meshheading:19151039-Liver Cirrhosis,
pubmed-meshheading:19151039-Male,
pubmed-meshheading:19151039-Middle Aged,
pubmed-meshheading:19151039-Phosphoric Acid Esters,
pubmed-meshheading:19151039-Plasma,
pubmed-meshheading:19151039-Sulfonamides,
pubmed-meshheading:19151039-Viral Load
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pubmed:year |
2009
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pubmed:articleTitle |
Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild-moderate liver impairment resulting from HCV-related cirrhosis.
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pubmed:affiliation |
Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy. francesca_gatti1@virgilio.it
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pubmed:publicationType |
Journal Article
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